We also compared the serum level of PZP in T2DM, T2MD + CRC and T2DM with lung adenocarcinoma (T2MD + LAC) patients, and the results showed that PZP was increased in T2MD + CRC and T2MD + LAC patients, but no difference was observed in these two groups (Supplementary Figure S3). This evidence concerns the gene PZP and lung adenocarcinoma.