As shown in Supplementary Figure S4, we could found that FUBP1/2, PON3 and FHR1 were increased in general CRC (CRC and T2DM + CRC) patients compared with non-CRC patients (NC + T2DM), while KV104 and FRPD2 were decreased (Supplementary Figure S4). The gene discussed is CFHR1; the disease is type 2 diabetes mellitus.