The standardized beta values of COVID-19 severity (148.953, p = 0.049), IL-6 (−0.411, p = 0.003), IL-23 (0.896, p = 0.001), and IL-1β (0.858, p = 0.023) were significant, while beta values of IL-12 and TNF-α did not reach statistical significance (Supplementary Table 4). The gene discussed is TNF; the disease is COVID-19.