In vitro, sustained TGF-β treatment induced cathepsin B (CTSB)-mediated degradation of Disabled-2 (Dab2), which activated autophagy and inhibited apoptosis by destabilizing the pro-apoptotic Bim protein, thereby modulating doxorubicin-resistance and tumor metastasis (Jiang et al., 2016). The gene discussed is CTSB; the disease is neoplasm.