Another study demonstrated that PFN2 is highly expressed in head and neck squamous cell cancer (HNSCC) tissues and cell lines and that the activation of the PI3K/Akt/β-catenin signaling pathway by PFN2 results in the proliferation and metastasis promotion of HNSCC, whereas PFN2 knockdown produces the opposite effects (Zhou et al., 2019). This evidence concerns the gene AKT1 and head and neck squamous cell carcinoma.