PFN2 and head and neck squamous cell carcinoma: Another study demonstrated that PFN2 is highly expressed in head and neck squamous cell cancer (HNSCC) tissues and cell lines and that the activation of the PI3K/Akt/β-catenin signaling pathway by PFN2 results in the proliferation and metastasis promotion of HNSCC, whereas PFN2 knockdown produces the opposite effects (Zhou et al., 2019).