GRK2 and Hypertension: (4) GRK2 deficiency induces para-vascular necroptosis, which then leads to fewer active TGCs at decidual portion and results in poor spiral artery remodeling in a dose-dependent pattern, (5) GRK2 deficiency in placenta is sufficient for the development of hypertension, renal dysfunction, and elevated angiogenic cytokines at late gestational age.