In chronic heart failure, increased levels of GRK2 promote the desensitization and down-regulation of the β adrenergic receptor (βAR), induce cardiac insulin resistance, and reduce free fatty acid utilization, increase catecholamine secretion from the adrenal gland and aldosterone level through β-Arrestin (Ciccarelli et al., 2020). The gene discussed is GRK2; the disease is congestive heart failure.