GRK2 and hypertensive disorder: In addition, the mice receiving 4 mg/kg GSK180736A daily from E8.5 to E13.5 and the mice intrauterine injected with GRK2-lentivirus at E8.5 developed PE-like phenotype: new-onset hypertension, proteinuria, and increased serum angiogenic cytokines from E14.5-E18.5.