Additional roles of biglycan in cancer cell proliferation, migration and metastasis were reported in tumor endothelial cells, where biglycan mediated tumor cell migration via TLR2/TLR4/NF-κB/Erk1/2 (201), in melanoma cells, where biglycan increased invasiveness by enhancing integrin-β1 expression (202), and in endometrial cancer cells, where knockdown of biglycan reduced migration, tubular formation and metastasis (203). Here, TLR4 is linked to neoplasm.