As the expression of PLPP4 was detected in various pancreatic cancer cell lines (Figure 11B), we constructed PLPP4-stably suppressing PANC-1 cells by endogenously knocking down PLPP4 via retroviral infection; meanwhile, we transfected of the constructed plasmid (vector, over-expression) into pancreatic cancer PANC-1 cells (Figures 11C, , D). Here, PLPP4 is linked to familial pancreatic carcinoma.