Meanwhile, PLPP4 was considered as a prognostic biomarker because PLPP4 showed “no-expression” or “expression” in normal tissues and carcinoma tissues, like ACC, BLCA, BRCA, DLBC, ESCA, HNSC, LAML, LUAD, LUSC, OV, PAAD, THYM, and so on (Figures 1A and 2). Here, PLPP4 is linked to adrenal cortex carcinoma.