Subsequent analysis of PLPP4 expression in different types of cancer datasets from TCGA and ArrayExpress showed that PLPP4 expression was upregulated in BLCA, BRCA, GBMLGG, HNSC, LUAD, LUSC, OV, PAAD, TGCT, THYM, and UCS tissues, and down-regulated in KIRC and KIRP compared that in the respective adjacent normal tissues and was further increased in LGG and PAAD tissues (Figures 2A–E). Here, PLPP4 is linked to pancreatic adenocarcinoma.