PLPP2 was higher in many cancers like adrenocortical carcinoma (ACC), cholangiocarcinoma (CHOL), colon adenocarcinoma (COAD), pancreatic adenocarcinoma (PAAD), and so on, while the level of PLPP2 was lower in kidney chromophobe (KICH), pheochromocytoma and paraganglioma (PCPG), skin cutaneous melanoma (SKCM), and so on. The gene discussed is PLPP2; the disease is hereditary pheochromocytoma-paraganglioma.