Xp11.2 tRCC with NONO–TFE3 and SFPQ–TFE3 are less common subtypes that show a combination of nested to papillary architecture with a secretory endometrioid appearance and subnuclear vacuoles, like clear cell papillary RCC. Here, TFE3 is linked to renal cell carcinoma associated with Xp11.2 translocations/TFE3 gene fusions.