MITF and renal cell carcinoma: Xp11.2 translocation carcinoma was first recognized as a subtype of renal cell carcinoma (RCC) in the 2004 World Health Organization classification of renal tumors (1), followed by being renamed as MiT (microphthalmia-associated transcription factor) family translocation renal cell carcinoma (tRCC) in the 2016 edition (2).