The hub genes (with a relatively high degree) in the PPI network of NSCLC-DEGs included Centromere protein F (CENPF; degree = 74), G2/mitotic-specific cyclin-B1 (CCNB1; degree = 67), G2/mitotic-specific cyclin-B2 (CCNB2; degree = 61), Cyclin-A2 (CCNA2; degree = 60), Mitotic checkpoint serine/threonine-protein kinase BUB1 (BUB1; degree = 56), and Aurora kinase B (AURKB; degree = 56) (Figure 5B and Additional File 6). Here, BUB1 is linked to non-small cell lung carcinoma.