VCP and amyotrophic lateral sclerosis: Indeed, VCP mutations have also been reported in patients with amyotrophic lateral sclerosis (ALS) (Matsubara et al., 2021), Charcot-Marie-Tooth type 2 (CMT2) disease (Gonzalez et al., 2014; Gite et al., 2020), and hereditary spastic paraplegia (HSP) (van de Warrenburg et al., 2016).