VCP’s role in protein degradation and autophagy is probably implicated in the pathogenesis of IBMPFD and may account for the cytoplasmic inclusions observed in muscle, bone, and neuronal tissue (Al-Obeidi et al., 2018; Kimonis et al., 2008). This evidence concerns the gene VCP and inclusion body myopathy with Paget disease of bone and frontotemporal dementia.