To elucidate the biological role and possible mechanisms of lncRNAs in ALI pathogenesis, GO along with KEGG pathway analyses were conducted, which revealed a close relationship with: the inflammatory response; developmental process; positive modulation of the cellular process; cell proliferation, differentiation, migration, and death; MyD88-dependent toll-like receptor signaling cascade; and metabolic process. The gene discussed is MYD88; the disease is acute respiratory distress syndrome.