TP53 and neoplasm: AURKA is abnormally expressed in a variety of tumors and regulates tumor proliferation, migration, invasion, and metastasis (Yan et al., 2016) In addition, it is involved in multiple signaling pathways, such as the TP53 pathway, Ras/mitogen-activated protein kinase (MAPK) pathway and NFKB pathway (Katayama et al., 2004; Briassouli et al., 2007; Umstead et al., 2017).