Referring to the results of Dana Sherill-Rofe and taking intersection with the 72 multigene panel used in our study, we obtained 18 genes and defined these genes as HRR genes, including ATM, ATR, BARD1, BRCA1, BRCA2, BRIP1, CHEK1, CHEK2, FANCA, FANCI, MRE11A, NBN, PALB2, RAD50, RAD51B, RAD51C, RAD51D and RAD54L. Most patients with germline HRR gene mutations are not sporadic and have at least one first and/or second-degree relatives who also have a tumor, which indicates that the germline mutations of HRR genes are closely related to heredity (Li et al., 2008). Here, NBN is linked to neoplasm.