PTEN and Hereditary breast cancer: The NCCN guideline list the susceptibility genes of hereditary breast cancer, including 6 high penetrance (BRCA1, BRCA2, CDH1, PALB2, PTEN and TP53) and 9 moderate to low penetrance (ATM, BARD1, BRIP1, CHEK2, NBN, NF1, RAD51C, RAD51D and STK11) susceptibility genes, most of which also participate in HRR pathway (Nielsen et al., 2016).