Cyanidin-3-glucoside, the main anthocyanin compound of black rice, suppresses the occurrence of high-fat-diet-induced obesity (Kongthitilerd et al., 2020), increases hyperglycemia and insulin sensitivity via AMP-activated protein kinase in type 2 diabetic mice (Takikawa et al., 2010). This evidence concerns the gene INS and Hyperglycemia.