Even though GRP94 facilitates the presentation of MHC class II-restricted peptides, CD4+T cells are not capable of secreting Th1 and Th2 effector cytokines (100).Immunization with autologous tumor-derived GRP94 of mice bearing methylcholanthrene-induced fibrosarcomas effectively induced anti-tumor response on day 7 after tumor challenge and was less effective when the treatment was started on day 9 after tumor challenge (101). This evidence concerns the gene CD4 and neoplasm.