Intriguingly, Chen and colleagues demonstrated that expression of stress-inducible HSP90α on the surface of tumor-cell released autophagosomes (TRAPs) promotes IL-6 production by CD4+ T cells via TLR2-Myeloid differentiation primary response protein 88 (MyD88)- NF-kB signalling pathway (108). This evidence concerns the gene IL6 and neoplasm.