TEK and Fabry disease: Indeed, treatment of AGAL-deficient EA.hy926 cells with 10 μM AKB-9778 resulted in an increase of L-fucose (48 h) and a decreased monocyte adhesion (72h), too (both p<0.001; Figures 2I, J), indicating that Tie2 and Angpt-2 are also involved in the observed glycocalyx degradation in FD.