These data are relevant to FD since drugs targeting the Tie2 pathway, such as AKB9778, are currently being investigated for the treatment of retinal vascular disease caused by diabetic nephropathy (39–41), hypertension in patients with diabetes mellitus (42) as well as the acute respiratory distress syndrome due to COVID-19 infections (NCT04511650). The gene discussed is TEK; the disease is acute respiratory distress syndrome.