Deficiency of Nrf2 suppressed cell proliferation, improved cell apoptosis with an increase in ROS and HO-1, and significantly increased the levels of chemokine 2 (Ccl2), interleukin-1β (IL-1β), tumor necrosis factor-alpha (TNF-α), angiotensin II receptor type 1 (AT1R), and reactive oxygen species (ROS) in the embryonic tissues, providing theoretical guidance for the application of Nrf2 in the treatment of preeclampsia (35). This evidence concerns the gene HMOX1 and preeclampsia.