Deficiency of Nrf2 suppressed cell proliferation, improved cell apoptosis with an increase in ROS and HO-1, and significantly increased the levels of chemokine 2 (Ccl2), interleukin-1β (IL-1β), tumor necrosis factor-alpha (TNF-α), angiotensin II receptor type 1 (AT1R), and reactive oxygen species (ROS) in the embryonic tissues, providing theoretical guidance for the application of Nrf2 in the treatment of preeclampsia (35). Here, CCL2 is linked to preeclampsia.