Additionally, a circular RNA, circPVT1, protects the myocardium from myocardial infarction (MI) and hypoxia/reoxygenation (H/R) injury by miR-125b/miR-200 sponges and then regulating Keap1/Nrf2- and Pdcd4-mediated apoptotic signaling (13). This evidence concerns the gene KEAP1 and myocardial infarction.