CXCL2 and neoplasm: In ovarian cancer, Snail1 accelerates cancer progression via up-regulation of CXCL1 and CXCL2 as well as recruitment of myeloid-derived suppressor cells (MDSCs) (145), which plays a vital role in cancer immunosuppression, tumor angiogenesis, drug resistance and promotion of tumor metastasis (146, 147).