SNAI1 and gastric cancer: In gastric cancer, phosphorylation of Snail1 is required for the F-box domain of FBXO31 to function (78), FBXW7 inhibits metastasis in part by binding to Snail1 (79) and FBXL5 promotes poly-ubiquitination of Snail1 at K85, K146 and K234 residues (80, 81).