Age (p = 0.855, OR = 1.043, 95% CI 0.667–1.628), KPS (p = 0.320, OR = 0.530, 95% CI 0.131–2.142), MGMT methylation (p = 0.888, OR = 0.969, 95% CI 0.628–1.495) and extent of resection (GTR: p = 0.599, OR = 0.822, 95% CI 0.551–1.411; PR: p = 0.555, OR = 1.2, 95% CI 0.654–2.201) were no independent predictors of OS in geriatric patients with glioblastoma. The gene discussed is MGMT; the disease is glioblastoma.