AGT and Hypertension: There is mounting evidence for several shared physiological responses across central AngII-mediated hypertension and our observation of Gαi2 protein-dependent salt sensitive hypertension including neuroinflammation and increased sympathetic outflow (Shi et al., 2010; Wainford et al., 2013; Moreira et al., 2019; Carmichael et al., 2020; Mohammed et al., 2020).