Evidenced by the fact that verified pharmacological antagonism of the AT1R with losartan did not impact the magnitude of hypertension in Gαi2 ODN infused rats on a high salt diet, our data suggest central AT1R activity does not play a role in the development of the salt sensitivity of blood pressure following the down-regulation of brain Gαi2 proteins. This evidence concerns the gene AGTR1 and Hypertension.