It inhibits the expression of vascular endothelial growth factor (VEGF) via alpha-1 hypoxia inducing factor degradation (HIF-1α) (Osada et al., 2004) and the growth of human cervical carcinoma HeLa cells and neuroblastoma cell lines, a paediatric tumour (Zheng et al., 2005). This evidence concerns the gene VEGFA and neuroblastoma.