The N. sativa extract (Figure 9G) and NS oil (Figure 9H) show moderate cytoplasmic positivity for VEGF in the ductal epithelial cells; thus, the NS extract and NS oil have anti-VEGF potential in this regime (Zhang et al., 2014) and demonstrated that berberine inhibits the expression of hypoxia-inducible factor 1α and increases the expression level of VEGF in prostate cancer. Here, VEGFA is linked to Familial prostate cancer.