Faah expression has been shown to be increased in the proximal colon in this model of inflammation (Storr et al., 2008a), indicating that colitis may alter FAAH at this time point, thus suggesting that the loss of function FAAH SNP we are exploring in the current study may confer some immunomodulatory benefit by reducing the impacts of this upregulation of FAAH. This evidence concerns the gene FAAH and colitis.