In vitro studies have shown that HSV-1 is capable of upregulating the processing of amyloid-beta precursor protein (AβPP), increasing Aβ, suggesting the possibility that the infection with HSV can contribute to Alzheimer’s Disease (AD) (Shipley et al., 2005; Harris and Harris, 2018). This evidence concerns the gene APP and early-onset autosomal dominant Alzheimer disease.