Apolipoprotein E (APOE) ε4 allele is an important genetic factor that increases susceptibility to sporadic AD (Scheltens et al., 2021) and has been associated with amyloid deposition, tau hyperphosphorylation, cholesterol transport (Scheltens et al., 2021), which can reportedly accelerate the progression to AD. This evidence concerns the gene MAPT and Alzheimer disease.