Since NR0B2 is involved in lipid and glucose metabolisms and inflammation, dysfunctionality in these processes may be associated with the risk of rapid mood cycling, this coincides with the higher rates of rapid cycling observed in BD patients with diabetes mellitus or insulin resistance (Ruzickova et al., 2003; Calkin et al., 2015). The gene discussed is NR0B2; the disease is Behcet disease.