In contrast, 1243 transcripts were differentially expressed between WT SHAM and WT DOCA mice (Fig. 5 and Supplementary Table 4); a typical cardiac hypertrophy and remodeling expression pattern, e.g., significant upregulation of actin alpha 1 (Acta 1, −4.8-fold change), Nppa (−3.2-fold change), and periostin (Postn −7.9-fold change), was observed in DOCA-treated WT mice (Supplementary Table 4). The gene discussed is ACTA1; the disease is cardiac hypertrophy.