The similar (in vivo) upregulation of Cpxm2 in the hearts of young animals at 4 weeks of age and before the development of sustained hypertension and in (in vitro) isolated cardiomyocytes and cardiofibroblasts corroborated a potential intrinsic role of Cpxm2 in LV remodeling in hypertension. Here, CPXM2 is linked to Hypertension.