MECP2 and autism spectrum disorder: For example, our finding in Mecp2-e1−/+ females that the reduced fecal abundance of Bacteroidetes was concurrent with an increase in Firmicutes was consistent with those of Strati et al.34 in human female patients with RTT, as well as in children with autism spectrum disorder (ASD)54 and in children with increased body mass index (BMI)55–57, suggesting a convergent profile reflective of humans with neurodevelopmental and metabolic dysfunction.