qRT-PCR analysis identified elevated expression of β-catenin target genes Axin2 and Lef1 in EdarTg951/951 tumour tissue (Fig. 4A), as well as elevated Edar transcript abundance when compared to untransformed EdarTg951/951 mammary tissue (Figs. 4A, 4B). Here, AXIN2 is linked to neoplasm.