Addition of iCRT3 to the culture medium suppressed proliferation of the tumour cells to levels that were not different from untransformed cells (Fig. 6B), demonstrating that β-catenin activity is required for elevated proliferative index of cells of the EdarTg951/951 tumours; we also observed a decrease in the expression of the Wnt target gene Lef1 in the iCRT3-treated tumour cells (Fig. S7B) but no change in the rate of apoptosis (Fig. S7C). Here, LEF1 is linked to neoplasm.