AKT1 and neoplasm: In cell experiments, XL147 inhibited the formation of PIP3 in the cell membrane and the phosphorylation of kinases such as Akt in a variety of tumor cell lines, influencing genetic alterations in the PI3K pathway.201 In mouse transplant models, the oral administration of XL147 inhibited the phosphorylation of Akt, p70S6K, and S6 for at least 24 h, and repeated administration of XL147 significantly inhibited tumor growth.201