The Wnt pathway is an important factor maintaining intestinal homeostasis; it regulates the self-renewal of stem cells and increases the proliferation of intestinal epithelial cells, and overactivation of the Wnt pathway may eventually lead to cancer.120,121 Some studies have shown an association between the Wnt/β-catenin and PI3K/Akt pathways in cancer. The gene discussed is AKT1; the disease is cancer.