AKT3 and cancer: Akt1 and Akt2 are enriched in many tissues, such as pancreatic tissue, while Akt3 is mainly expressed in the brain, and its expression is very limited by its tissue distribution.31 Different Akt isoforms play different and vital roles in cancer; for example, Akt2 is involved in cancer cell migration and invasion, and Akt3 is associated with hormone independence.31,32 Moreover, Akt2 gene expression is amplified in pancreatic cancer, while Akt3 is overexpressed in breast and prostate cancer, and both Akt2 and Akt3 are insensitive to hormones.33