PTEN is a tumor suppressor that is key for maintaining normal physiological activity; PTEN was initially identified as a gene prone to mutations in multiple types of sporadic tumors.71 The C2 domain houses the PTEN lipid substrate and is necessary for the proper localization of PTEN on the plasma membrane; PTEN has shown affinity for the phospholipid membrane in vitro.72 Nuclear PTEN is important for the maintenance of chromosomal integrity and centromere stability.73 This evidence concerns the gene PTEN and neoplasm.