Activated PI3K/Akt signaling promotes the uptake of glucose and amino acids by CD8+ T cells for energy-demanding cellular processes, such as proliferation and cytokine synthesis and secretion.186 Moreover, research has shown that Akt inhibition effectively enhances memory T cell differentiation in cancer.187 Therefore, inhibition of the PI3K/Akt signaling pathway may affect T cell function. Here, PIK3CA is linked to cancer.