PIK3CD and cancer: A regulatory circuit between the EGFR/PI3K/Akt/mTORC1 and IKK/NF-κB signaling pathways has been identified in cancer.119 The EGFR/PI3K/Akt/mTORC1 signaling pathway regulates the IKK/NF-κB signaling pathway, while IKK/NF-κB also regulates EGFR expression and subsequently modulates the PI3K/Akt pathway.