In tumor invasion and metastasis, platelet-derived growth factor (PDGF) induces MMP expression through a PI3K-mediated signaling pathway.162 Upregulation of the antiapoptotic protein Bcl-2 and activation of the PI3K/Akt signaling pathway are the main mechanisms by which COX-2 stimulates endothelial angiogenesis.163. This evidence concerns the gene AKT1 and neoplasm.