The NF-κB TF family includes components such as p50 and p65; NF-κB is a heterodimer that is isolated in the cytoplasm by inhibitor of kappa B (IκB).116 Upon the phosphorylation of IκB, NF-κB is released, enabling its nuclear translocation and binding to genes involved in processes such as cell proliferation and angiogenesis in esophageal cancer.117 Some studies have suggested that Akt signaling phosphorylates IκB kinase α to activate NF-κB TFs, which are downstream of multiple signaling pathways.118. This evidence concerns the gene AKT1 and esophageal cancer.