PIK3CA and neoplasm: Studies have shown that the positive effect of Akt signaling on inflammatory cells is conducive to promoting the aggregation of reactive cells, and the resulting oxidative stress reaction leads to the accumulation and release of peroxides (ROS) at the tumor site.173 In addition, IL-37 is an anti-inflammatory cytokine that has been reported to induce autophagy and apoptosis by regulating PI3K/Akt/mTOR signaling.174