METTL14 and colorectal carcinoma: Moreover, we assessed the effect of METTL14 on CRC metastasis in vivo, and the results demonstrated that suppression of METTL14 significantly induced CRC liver metastasis in CRC xenograft derived from HCT116 cells with low METTL14 expression, as indicated by magnetic resonance imaging (MRI) scans (Fig. 2I) and the number of liver metastatic lesions (Fig. 2J–L).