To verify whether HMGB1 and RICTOR are both target genes of the miR-200 family (miR-200a/200b/429) in HCC, luciferase reporter gene plasmids were constructed with either wild-type 3′UTR (3′UTRWT) or mutated binding sites of miR-200a/200b/429 in 3′UTR (3′UTRMUT) of HMGB1 and RICTOR mRNAs. This evidence concerns the gene RICTOR and hepatocellular carcinoma.