Note that, flow cytometry analysis indicated a higher proportion of PD-L1+ exosomes released by liver cells that overexpress HMGB1/RICTOR 3′UTR (Fig. 5c), while the HMGB1/RICTOR interference HCC cell lines produced significantly fewer PD-L1+ exosomes (Fig. 5c). The gene discussed is HMGB1; the disease is hepatocellular carcinoma.