To more solidly identify what HMGB1 and RICTOR “RNA–RNA” crosstalk does in HCC cells, we transfected QSG-7701 cell line with HMGB1/RICTOR 3′UTR-overexpression plasmid harboring muted binding sites of miR-200 family. The gene discussed is HMGB1; the disease is hepatocellular carcinoma.