CD4 and lymphedema: In summary, WILD syndrome is a clinically recognisable condition characterised by congenital multisegmental lymphoedema (often asymmetrically distributed and usually of early onset) with systemic involvement, cutaneous lymphovascular malformations, severe and persistent warts and epidermal naevi in association with CD4 lymphopaenia (and consequently low CD4:CD8 ratios), but normal monocyte counts.