INS and alkaline phosphatase measurement: We observed significant enrichments in several GO terms that are closely connected to AP pathology (Fig. 2D, Additional file 2: Table S5), including regulation of cellular response to insulin stimulus and regulation of peptide hormone secretion that are associated with normal pancreas functions; or regulation of metanephros development and foregut morphogenesis that are associated with non-pancreas organs that are often damaged during SAP (kidney and upper digestive track, respectively).