The two variables representing gastrointestinal phenotypes (gastroesophageal reflux disease [GERD] and drugs for peptic ulcers and GERD) had the most associations, with 24 and 27 OTUs respectively, followed by anxiolytics (anti-anxiety drugs) with 27, analgesics (pain killers) with 23, estrogens with 21, and insulin and hypoglycemic drugs with 18 associated OTUs. This evidence concerns the gene INS and peptic ulcer disease.