EGF and neoplasm: In vitro and in vivo studies based on head and neck squamous carcinoma model showed that EGF/cisplatin/CNTs exhibited the best active targeting ability and the strongest cytotoxicity to tumor cells, which could inhibit the tumor growth to the greatest extent compared to other groups without EGF modification, further demonstrating that the active targeting ability of the whole DDS could be enormously improved with the existence of EGF, while the potential adverse effects due to the lack of specificity could be accordingly avoided.