The μCT results demonstrated there was abnormal subchondral bone remodeling as represented by a turnover from enhanced bone loss at 4 weeks postoperatively to enhanced osteosclerosis at 8 weeks postoperatively, which was consistent with the number of osteoclasts stained by TRAP in subchondral bone and the OARSI scores represented by Safranin O-Fast Green staining. The gene discussed is ACP5; the disease is osteosclerosis.