To investigate the function of SOAT1 on colorectal tumorigenesis induced in miR-148a–/– mice, we then crossed Soat1ΔIE mice with miR-148a–/– mice to generate miR-148a–/– Soat1ΔIE mice for inducing CRC with AOM/DSS. This evidence concerns the gene SOAT1 and colorectal carcinoma.