These estimates are consistent with previous studies in Honduras with the incidence of 30.8 and 13.9 in males and females.16 The high incidence of gastric cancer has been attributed to endemic Helicobacter pylori infection with virulent strains (eg, cagA), germline genetic influences, and environmental exposures (eg, wood stoves).35-37. The gene discussed is S100A8; the disease is gastric cancer.