RPS27A was also shown to be elevated in chronic myeloid leukemia (CML) and acute leukemia, and knockdown of RPS27A in CML K562 cell lines decreased cell proliferation, arrested cells at the S and G2/M phases, and promoted apoptosis [24]. The gene discussed is RPS27A; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.