To analyze the repertoire of small RNAs produced upon SARS‐CoV‐2 infection with potential regulatory functions, we generated 5′ monophosphate‐dependent small RNA libraries from human colorectal adenocarcinoma cells (Caco‐2), an intestinal cellular model, and human pulmonary ACE2‐expressing A549 (A549‐ACE2) cells, both known to be highly susceptible to SARS‐CoV‐2 infection (Chu et al, 2020; Takayama, 2020). Here, ACE2 is linked to colorectal adenocarcinoma.