DNMT1 and Insulin resistance: When compared with untreated cells, we also found that DEX or TNF-α treatment of C2C12 cells induced insulin resistance, as demonstrated by the inactivation of mTOR (ESM Fig. 7a, b), and reduced Dnmt1 expression (ESM Fig. 7c, e) and enhanced expression of miR-193b (ESM Fig. 7d, f).