Notably, although the DNAzyme targeting GLUT1 mRNA of HL‐7702 cells was obtained (Figure S22, Supporting Information), the cytotoxicity of HZ@GD on HL‐7702 cells was far less than B16‐F10 cells (Figure S23, Supporting Information), suggesting the preferential inhibition of “nanoenabled energy interrupter” on melanoma cells. This evidence concerns the gene SLC2A1 and melanoma.