In summary, “nanoenabled energy interrupter” could selectively induce Zn2+ overloading in tumor cells, the underlying mechanism is the difference of the original Zn2+ levels and expression of Zn2+ efflux protein ZnT1 between tumor cells and normal cells, as well as tumor cell targeting effect of HA (Figure 2f). This evidence concerns the gene SLC30A1 and neoplasm.