To be specific, blood parameters are five clinically feasible biochemical indicators including glucose (GLU), TG, TC, apolipoprotein A1 (ApoA1), and apolipoprotein B (ApoB), and nine dementia biomarkers that represent the subjects' brain health states including ApoE genotype, HCY, NFL, Triggering Receptor Expressed on Myeloid cells 2 (TREM2), Aβ40, Aβ42, T‐tau, Tissue Inhibitor of Metalloproteinases 1 (TIMP1), and Very Low Density Lipoprotein Receptor (VLDLR). The gene discussed is TIMP1; the disease is dementia.