CDKL5 and craniodiaphyseal dysplasia: However, the majority of Cdkl5 KO mice models display only minor motor function deficits, with small alterations observed in their gait suggesting a mild coordination disturbance, and do not exhibit spontaneous seizures as observed in CDD patients (Amendola et al., 2014; Okuda et al., 2018; Wang et al., 2012).