In U87 glioblastoma cells, Con A induces expression of membrane-associated MT1-MMP, which functions in PGE2-induced angiogenesis, activation of pro-MMP-2, and cell death/survival regulation/survival bio-switch activating IKKa and IκB-NF-κB complexes (Sina et al. The gene discussed is MMP2; the disease is glioblastoma.