In this study, we demonstrated that it had a positive correlation between FGFR1 and LIN28B (Figures S3 and S4), and C1632 suppressed the expression of LIN28 and blocked FGFR1 signalling in NSCLC A549 and A549R cells (Figure 2), resulting in an inhibition of migration (Figure 3 and Figure S6) and proliferation (Figure 5) of A549 and A549R cells in vitro and in vivo. The gene discussed is FGFR1; the disease is non-small cell lung carcinoma.