LDHA and pancreatic ductal adenocarcinoma: In human pancreatic ductal adenocarcinoma (PDAC) cells, highly expressed KAT2A regulates H3K79 succinylation in the promoter region of YWHAZ (encoding for 14-3-3ζ) to promote 14-3-3ζ expression, thereby preventing β-catenin degradation and subsequently increasing the expression of cyclin D1, c-Myc, GLUT1, and lactate dehydrogenase A (LDHA) to promotes glycolysis, cell proliferation, and migration and invasion of PDAC cells (Tong et al., 2020).