APP and Alzheimer disease: A recent PIB-PET imaging study in non-demented older adults reported that a lifetime coffee intake of 2 or more cups per day was significantly associated with lower brain Aβ positivity, suggesting a direct relationship between coffee consumption and APP metabolism [10] and levels of the caffeine metabolite theobromine showed a significant correlation with CSF Aβ42 levels in AD and MCI patients [9].