AKT1 and melanoma: Pathways in tumorigenesis, including PI3K-AKT (P = 3.39e − 04), RAS (P = 0.0012), MAPK (P = 0.0015), melanoma (P = 0.0023), and WNT signaling pathways (P = 0.0073), were significantly downregulated (Figures 1(c) and 1(d)).